Plural Polymer Technology
Mithra has a strong heritage in Polymer Technology for long acting drug development
Experience in developing multiple drug delivery strategies for drug / device combination products gained by successful preliminary development including:
- Broad range of APIs and duration (1 week up to 5 years)
- Biodegradables or non-biodegradables forms
- Multiple administraton routes: vaginal, intra-uterine, sub-cutaneous / intra-muscular injection
- Multiple pharmaceutical forms: rings, implants, Intra-Uterine device, gels, microsphères
- Flexible processes of extrusion and co- extrusion, molding, device assembling…
- Development of medical device part
Characteristics of a long acting drug
► Prolonged drug delivery technology
► Predetermined rate of API distribution
► Controlled release / Targeted delivery
► Wide range of opportunities in drug delivery development for multiple therapeutic fields: virology, oncology, sexual hormones, CNS…
Projects
Product candidate: Zoreline, biodegradable SC implant
- Hybrid analogue of Zoladex®
- Zoladex® is a bio-degradable subcutaneous implant preloaded in a single use safety syringe for prostate and breast cancer and benign gynaecological indications
- Releases 3.6mg or 10.8 mg of gosereline acetate per injection for 1 or 3 months
Myring®, contraceptive vaginal ring
- Analogue of NuvaRing®
- NuvaRing® is a combined hormonal contraceptive vaginal ring
- Releases 120 µg of etonogestrel and 15 µg of ethinylestradiol per day for a menstrual cycle of 21 days
Sterile Injectables
Mithra offers the latest generation, highly flexible, multiform sterile injectables manufacturing platform to its partners
- Nested and Ready to use Technology
- Flexible aseptic manufacturing process
- Adaptable to multiple pharmaceutical forms and APIs (hormones, non hormones)
- Forms: Vials, ready-to-use cartridges, ready-to-use syringes
Hormonal Tablets
Latest generation multi products, flexible and efficient hormonal/non-hormonal manufacturing environment
- Historical heritage in hormonal tablets
- Production at an industrial scale of hormonal and non-hormonal tablets
- Highly flexible production line able to produce more than 10 different types of tablets
- Forms: Coated & uncoated tablets
- Process: Full range of tablets using a wet granulation process or a direct compression process
